Glasgow A M, Chase H P
Pediatr Res. 1975 Mar;9(3):133-8. doi: 10.1203/00006450-197503000-00005.
4-Pentenoic acid, an analog of hypoglycin which is believed to cause Jamaican vomiting sickness, was administered intraperitoneally to rats in an attempt to produce the features of Reye's syndrome in rats. Mean ammonia levels in plasma were found to be elevated approximately four-fold after injection of 200 mg/kg pentenoic acid in fed rats. Pentenoic acid caused hypoglycemia in fasted rats and hyperglycemia in fed rats. In chronic experiments rats were injected intraperitoneally every 4 hr with 50 mg/kg body weight of pentenoic acid for 10 doses, followed by a single dose of 200 mg/kg. The livers of the treated group were enlarged and yellow and showed extensive fatty degeneration. The blood-urea-nitrogen (BUN) was significantly higher and the free fatty acids (FFA's) significantly lower in these rats. This study shows that pentenoic acid administered to rats produces findings similar to those of Reye's syndrome and Jamaican vomiting sickness.
4-戊烯酸是一种被认为会导致牙买加呕吐病的降糖氨酸类似物，为了在大鼠身上产生瑞氏综合征的特征，将其腹腔注射给大鼠。在给喂食的大鼠注射200毫克/千克戊烯酸后，发现血浆中的平均氨水平升高了约四倍。戊烯酸在禁食大鼠中引起低血糖，在喂食大鼠中引起高血糖。在慢性实验中，大鼠每4小时腹腔注射50毫克/千克体重的戊烯酸，共注射10次，随后单次注射200毫克/千克。治疗组大鼠的肝脏肿大且发黄，并出现广泛的脂肪变性。这些大鼠的血尿素氮（BUN）显著升高，游离脂肪酸（FFA）显著降低。这项研究表明，给大鼠注射戊烯酸会产生与瑞氏综合征和牙买加呕吐病相似的结果。
