Gimelli G, Di Mario C, Liistro F, Dharmadhikari A V, Montorfano M, Anzuini A, Vaghetti M, Puchala-Borowik M, Airoldi F, Carlino M, Tzifos V, Maisano F, Alfieri O, Colombo A
Department of Interventional Cardiology, Columbus Hospital, Milan, Italy.
Ital Heart J. 2001 Jan;2(1):21-4.
Coronary artery bypass surgery and angioplasty provide symptomatic relief in patients with ischemic heart disease, but despite advancement in technique and devices, these methods are not applicable to a subset of patients with angina refractory to medical treatment. Bypass surgery might not be feasible because of lack of suitable conduits, diffuse coronary disease or poor distal run-off, and coronary angioplasty is sometimes not applicable due to chronic total occlusion, diffuse disease or extreme tortuosity. We have previously reviewed the available experience with laser-induced direct myocardial revascularization, one of the new potential treatment modalities for this patient subset. One of the potential mechanisms of action for laser treatment is the induction of neoangiogenesis. In the second part of our article we review the available experience with the induction of myocardial angiogenesis using different growth factors or the genes encoding for them.
冠状动脉搭桥手术和血管成形术可缓解缺血性心脏病患者的症状，但尽管技术和设备有所进步，这些方法并不适用于一部分对药物治疗无效的心绞痛患者。由于缺乏合适的血管、弥漫性冠状动脉疾病或远端血流不佳，搭桥手术可能不可行，而冠状动脉成形术有时因慢性完全闭塞、弥漫性疾病或极度迂曲而不适用。我们之前回顾了激光诱导直接心肌血运重建术的现有经验，这是针对该类患者的一种新的潜在治疗方式。激光治疗的潜在作用机制之一是诱导新生血管形成。在本文的第二部分，我们回顾了使用不同生长因子或其编码基因诱导心肌血管生成的现有经验。
