Patek A J, Bowry S, Hayes K C
Proc Soc Exp Biol Med. 1975 Feb;148(2):370-4. doi: 10.3181/00379727-148-38541.
One of five rhesus monkeys fed a diet deficient in choline and protein for 31 mo developed signs of cirrhosis at 26 mo. Five other monkeys were fed the same diet for 14 mo, at which time cholesterol comprising 2% of the diet was added. Three followed a sharp rise in hepatic lipids. One monkey developed marked hypercholesterolemia and showed signs of cirrhosis 2 mo after cholesterol supplementation. The findings indicate that the rhesus monkey is susceptible to choline-deficiency cirrhosis. They suggest that cholestrol supplementation accelerates this process.
五只恒河猴中有一只喂食缺乏胆碱和蛋白质的饮食31个月，在26个月时出现肝硬化迹象。另外五只猴子喂食相同饮食14个月，之后在饮食中添加占比2%的胆固醇。三只猴子的肝脏脂质急剧上升。一只猴子在补充胆固醇两个月后出现明显的高胆固醇血症并表现出肝硬化迹象。研究结果表明恒河猴易患胆碱缺乏性肝硬化。研究结果还表明补充胆固醇会加速这一过程。
