Arteaga de Murphy C, Ferro-Flores G, Pedraza-López M, Meléndez-Alafort L, Croft B Y, Ramírez F M, Padilla J
Departamento de Medicina Nuclear, Instituto Nacional de Nutrición Salvador Zubirán, México DF, Mexico.
Appl Radiat Isot. 2001 Mar;54(3):435-42. doi: 10.1016/s0969-8043(00)00296-7.
Etidronate and medronate have been labelled with technetium-99m (99mTc-HEDP, 99mTc-MDP) for bone scanning and, with rhenium-188 (188Re-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-188Re. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [188Re]Re-ABP and similarities with 99mTc-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation.
依替膦酸盐和甲羟膦酸盐已用锝-99m（99mTc-HEDP、99mTc-MDP）标记用于骨扫描，并用铼-188（188Re-HEDP）缓解骨转移引起的疼痛。本研究的目的是用SnF2还原的188Re标记一种新的双膦酸盐阿仑膦酸盐（ABP）。5mg ABP试剂盒的试剂为酸性pH条件下的SnF2、高铼酸钾和龙胆酸。介绍了[188Re]Re-ABP的化学、光谱和微观特征、质量控制、大鼠骨摄取情况以及与99mTc-ABP的相似性。我们得出结论，这是一种用于缓解骨转移疼痛的有前景的新型放射性药物。
