Demaimay R, Chesebro B, Caughey B
RML, NIAID, NIH, Hamilton, Montana 59840, USA.
Arch Virol Suppl. 2000(16):277-83. doi: 10.1007/978-3-7091-6308-5_26.
Five compounds related to Congo Red were found to inhibit generation of protease-resistant prion protein in a cell-free system. In this assay Trypan Blue, Evans Blue, Sirius Red F3B, Primuline and Thioflavin-S were all more inhibitory than Congo Red itself. In scrapie-infected mouse neuroblastoma cells one compound, Sirius Red F3B, was capable of blocking the formation of protease-resistant prion protein to a similar extent as Congo Red; however, the other four compounds were less effective. Some of these compounds should be considered for testing in TSE disease models in live animals.
