Bayhan G, Bahçeci M, Demirkol T, Ertem M, Yalinkaya A, Erden A C
Department of Obstetrics and Gynecology, Dicle University, Diyarbakir Turkey.
Clin Exp Obstet Gynecol. 2000;27(3-4):203-6.
To compare the efficacy of finasteride and GnRH agonist in the treatment of idiopathic hirsutism.
Sixty women with hirsutism were randomly assigned to receive either 5 mg of finasteride or long-acting GnRH agonist (depot leuprolide 3.75 mg) intramuscularly monthly for six months.
Hirsutism scores were measured according to the Ferriman-Gallway scoring system, and side-effects were monitored for six months of treatment. Blood samples were taken at each visit for assessment of endocrine (FSH, LH, estradiol, progesterone, total and free testosterone, androstenedione, DHEAS-S, 17-OH-P. SHBG), biochemical, and hematologic para- meters.
All of the patients treated with finasteride or GnRH agonist showed neither menstrual abnormalities nor side-effects. The mean percent change (+/- SD) in hirsutism scores in the GnRH and finasteride groups was 36% +/- 14% and 14% +/- 11% at six months, respectively. Serum total testosterone, free testosterone, androstenedion and DHEA-S showed a meaningful decrease in patients treated with GnRH agonist. On the other hand, only serum total testosterone and free testosterone levels decreased with finasteride treatment (p < 0.05 and p < 0.0001, respectively).
比较非那雄胺和促性腺激素释放激素（GnRH）激动剂治疗特发性多毛症的疗效。
将60例多毛症女性随机分为两组，分别接受每月一次肌肉注射5mg非那雄胺或长效GnRH激动剂（长效亮丙瑞林3.75mg），共治疗6个月。
根据费里曼-盖尔韦评分系统测量多毛症评分，并在治疗6个月期间监测副作用。每次就诊时采集血样，评估内分泌（促卵泡生成素、促黄体生成素、雌二醇、孕酮、总睾酮和游离睾酮、雄烯二酮、硫酸脱氢表雄酮、17-羟孕酮、性激素结合球蛋白）、生化和血液学参数。
所有接受非那雄胺或GnRH激动剂治疗的患者均未出现月经异常或副作用。6个月时，GnRH组和非那雄胺组多毛症评分的平均变化百分比（±标准差）分别为36%±14%和14%±11%。接受GnRH激动剂治疗的患者血清总睾酮、游离睾酮、雄烯二酮和硫酸脱氢表雄酮水平有显著下降。另一方面，非那雄胺治疗仅使血清总睾酮和游离睾酮水平下降（分别为p<0.05和p<0.0001）。
