Brace R A, Scott J B, Chen W T, Anderson D K, Haddy F J
Proc Soc Exp Biol Med. 1975 Feb;148(2):578-83. doi: 10.3181/00379727-148-38587.
Hemodialysis was used to study the direct effects of acute hypoosmolality upon the resistance to blood flow through the gracilis and coronary vascular beds and upon left ventricular contractile force in the dog. When sodium chloride was removed from the blood perfusing the gracilis vascular bed, resistance increased linearly over the range 300-225 mOsm/kg. A 10% decrease in osmolality produces a 20% increase in resistance. When the removed sodium dhloride was replaced with mannitol such that plasma osmolality did not change, resistance rose slightly but failed to regularly return to the control value. Hypoosmolality also raised coronary vascular resistance and this was associated with an increase in left ventricular force. Thus direct effects of hypoosmolality on peripheral vascular beds and perhaps myocardium may participate in the compensatory mechanisms that tend to stabilize blood pressure during hypoosmotic states such as acute salt depletion.
采用血液透析法研究急性低渗状态对犬股薄肌和冠状血管床血流阻力以及左心室收缩力的直接影响。当从灌注股薄肌血管床的血液中去除氯化钠时，在300 - 225毫渗摩尔/千克范围内，阻力呈线性增加。渗透压降低10%会使阻力增加20%。当用甘露醇替代去除的氯化钠以使血浆渗透压不变时，阻力略有上升，但未能规律地恢复到对照值。低渗状态还会升高冠状血管阻力，这与左心室力量增加有关。因此，低渗状态对外周血管床以及可能对心肌的直接影响，可能参与了在急性盐耗竭等低渗状态下倾向于稳定血压的代偿机制。
