利用正电子发射断层扫描评估食管鳞状细胞癌中的淋巴结转移情况。
Evaluation of lymph node metastases in squamous cell carcinoma of the esophagus with positron emission tomography.
作者信息
Kim K, Park S J, Kim B T, Lee K S, Shim Y M
机构信息
Department of Thoracic and Cardiovascular Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
出版信息
Ann Thorac Surg. 2001 Jan;71(1):290-4. doi: 10.1016/s0003-4975(00)02221-9.
BACKGROUND
Previous studies suggest positron emission tomography (PET) may improve staging accuracy of esophageal cancer compared with conventional methods, especially in detecting occult distant metastases. We evaluated the accuracy of PET in the detection of lymph node metastasis prospectively with pathologic findings.
METHODS
Fifty-three patients with squamous cell carcinoma underwent whole-body PET scan and chest computed tomography (CT). The findings of PET and chest CT of 50 patients who underwent curative esophagectomy with radical lymph node dissection were compared with the pathologic findings.
RESULTS
Among 53 primary esophageal tumors, PET detected 51 (96.2%) and CT detected 49 (92.5%) tumors correctly. Nodal metastases were present in 108 of 436 dissected lymph node groups. PET detected 56 metastatic node groups (51.9% sensitivity, 94.2% specificity, 83.7% accuracy), compared with CT, which detected 16 (14.8% sensitivity, 96.7% specificity, 76.6% accuracy; sensitivity: p < 0.005).
CONCLUSIONS
PET was more sensitive than CT in the detection of nodal metastases and may improve staging of squamous cell carcinoma of the esophagus.
背景
先前的研究表明，与传统方法相比，正电子发射断层扫描（PET）可能会提高食管癌分期的准确性，尤其是在检测隐匿性远处转移方面。我们通过病理结果前瞻性地评估了PET检测淋巴结转移的准确性。
方法
53例鳞状细胞癌患者接受了全身PET扫描和胸部计算机断层扫描（CT）。将50例行根治性食管切除术并根治性淋巴结清扫术患者的PET和胸部CT检查结果与病理结果进行比较。
结果
在53个原发性食管肿瘤中，PET正确检测出51个（96.2%），CT正确检测出49个（92.5%）肿瘤。在436个清扫的淋巴结组中，有108个存在淋巴结转移。PET检测出56个转移淋巴结组（敏感性51.9%，特异性94.2%，准确性83.7%），而CT检测出16个（敏感性14.8%，特异性96.7%，准确性76.6%；敏感性：p<0.005）。
结论
PET在检测淋巴结转移方面比CT更敏感，可能会改善食管鳞状细胞癌的分期。
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