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在加纳利用社区志愿者分发阿奇霉素以控制沙眼的试点研究。

Pilot study of the use of community volunteers to distribute azithromycin for trachoma control in Ghana.

作者信息

Solomon A W, Akudibillah J, Abugri P, Hagan M, Foster A, Bailey R L, Mabey D C

机构信息

Clinical Research Unit, London School of Hygiene and Tropical Medicine, England.

出版信息

Bull World Health Organ. 2001;79(1):8-14. Epub 2003 Nov 5.

PMID:11217675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2566341/
Abstract

OBJECTIVE

To assess the skills of community health volunteers in diagnosing active trachoma and distributing azithromycin in the Northern Region of Ghana.

METHODS

Six community health volunteers from Daboya were trained to diagnose trachoma and to treat the disease using azithromycin. They were also informed of the drug's possible side-effects. Under supervision, each volunteer then examined, and if necessary treated, 15 households. The dose of azithromycin was determined by weight; height was also measured. Tablets were given in preference to suspension when possible.

RESULTS

The volunteers' diagnostic sensitivity for active trachoma was 63%; their specificity was 96%. At the household level, their "decision to treat" was correct in 83% of households. In 344 treatment episodes, volunteers planned a dose of azithromycin outside the range 15-30 mg/kg on only seven occasions (2.0% of all planned treatments). The volunteers' drug management skills were good, the response of the community was excellent, and adverse reactions were infrequent. Diagnosis of active trachoma, record-keeping skills, and knowledge of side-effects were found to need greater emphasis in any future education programme. Most people aged four years or older were able to swallow tablets. For those taking tablets, the correlation between the data gathered for height and weight shows that calculating azithromycin doses by height is a valid alternative to calculating it by weight.

CONCLUSION

Trained community health volunteers have a potential role in identifying active trachoma and distributing azithromycin. To simplify training and logistics, it may be better to base dosage schedules on height rather than weight for those taking tablets, which included most people aged four years or more in the population studied.

摘要

目的

评估加纳北部地区社区卫生志愿者诊断活动性沙眼及分发阿奇霉素的技能。

方法

来自达博亚的六名社区卫生志愿者接受了诊断沙眼及使用阿奇霉素治疗该病的培训。他们也被告知该药可能的副作用。在监督下,每名志愿者随后检查了15户家庭,必要时进行治疗。阿奇霉素的剂量根据体重确定;同时测量身高。可能的情况下优先给予片剂而非混悬液。

结果

志愿者对活动性沙眼的诊断敏感性为63%;特异性为96%。在家庭层面,他们“治疗决定”在83%的家庭中是正确的。在344次治疗过程中,志愿者仅7次(占所有计划治疗的2.0%)计划的阿奇霉素剂量超出15 - 30mg/kg范围。志愿者的药物管理技能良好,社区反应极佳,不良反应很少见。发现未来任何教育项目中都需要更加强调活动性沙眼的诊断、记录保存技能及副作用知识。大多数4岁及以上的人能够吞服片剂。对于吞服片剂的人,收集的身高和体重数据之间的相关性表明,按身高计算阿奇霉素剂量是按体重计算的有效替代方法。

结论

经过培训的社区卫生志愿者在识别活动性沙眼和分发阿奇霉素方面具有潜在作用。为简化培训和后勤工作,对于吞服片剂的人(在所研究人群中包括大多数4岁及以上的人),基于身高而非体重制定剂量方案可能更好。