[破伤风、白喉和脊髓灰质炎联合疫苗。免疫原性和耐受性的随机对照研究]

[Combined vaccine against tetanus, diphtheria and polio. A randomized controlled study of immunogenicity and tolerance].

作者信息

Banzhoff A, Donner-Banzhoff N, Schwenke C, Girgsdies O E, Jilg W

出版信息

Fortschr Med Orig. 2001 Jan 11;118(4):169-72.

Abstract

UNLABELLED

BACKGROUND, METHOD: Given the worldwide distribution of infection and the mobility of large parts of the population immunizations against tetanus, diphtheria and polio remain a challenge. This is especially true for adolescents and adults since antibodies tend to wane once immunized children enter adolescence and adulthood. A new combination vaccine against tetanus, diphtheria and polio (Td-IPV) for booster immunizations was subjected to a randomized, controlled and single-blind trial. Non-inferiority had to be demonstrated with regard to efficacy (immunogenicity) and safety in comparison to separate Td and IPV injections.

RESULTS

Almost 500 subjects from community practices and occupational/immunization clinics took part. Antibody titres were equivalent for all antigens. Local and systemic reactions were equal or even less marked in the intervention group.

CONCLUSION

From a public health perspective the new vaccine can make an important contribution to ensure adequate protection against tetanus, diphtheria and polio in adolescent and adult populations.

摘要

未标注

背景、方法：鉴于感染在全球范围内的传播以及大部分人口的流动性，破伤风、白喉和脊髓灰质炎的免疫接种仍然是一项挑战。对于青少年和成年人来说尤其如此，因为一旦接种疫苗的儿童进入青春期和成年期，抗体往往会减弱。一种用于加强免疫的新型破伤风、白喉和脊髓灰质炎联合疫苗（Td-IPV）进行了一项随机、对照和单盲试验。与单独注射Td和IPV相比，必须在疗效（免疫原性）和安全性方面证明其非劣效性。