Imoto I, Taguchi Y
Third Department of Internal Medicine, Mie University School of Medicine.
Nihon Rinsho. 2001 Feb;59(2):328-32.
Helicobacter pylori (H. pylori) infection is the cause of the frequent relapse of peptic ulcer disease. Successful eradication therapy of H. pylori is associated with a decline in the recurrence of peptic ulcer. In this paper, we discussed the significance of anti-ulcer therapy after H. pylori eradication therapy. In patients with duodenal ulcer, maintenance therapy for preventing ulcer recurrence is not necessary because the rate of ulcer recurrence after eradication therapy is very low. However, in patients with gastric ulcer, the rate of ulcer relapse and reflux esophagitis ranges between 5-10% in the Japanese population even after successful eradication therapy; therefore, maintenance therapy for 1 year may be permissible in patients with gastric ulcer even after successful eradication therapy.
幽门螺杆菌（H. pylori）感染是消化性溃疡疾病频繁复发的原因。成功根除幽门螺杆菌的治疗与消化性溃疡复发率的下降有关。在本文中，我们讨论了幽门螺杆菌根除治疗后抗溃疡治疗的意义。对于十二指肠溃疡患者，由于根除治疗后溃疡复发率非常低，因此无需进行预防溃疡复发的维持治疗。然而，对于胃溃疡患者，即使在成功根除治疗后，日本人群中溃疡复发和反流性食管炎的发生率仍在5%-10%之间；因此，即使在成功根除治疗后，胃溃疡患者进行1年的维持治疗可能是可行的。
