Kodama M, Fujioka T, Murakami K, Sato R
Department of General Medicine, Oita Medical University.
Nihon Rinsho. 2001 Feb;59(2):333-6.
Helicobacter pylori (H. pylori) infection is recognized to be a pathogen of various gastro-duodenal disease. Eradication therapy of H. pylori reduces the recurrence of gastro-duodenal ulcer, improves gastritis histologicaly, and is suggested to act an certain role in protection against gastric carcinogenesis. Although, several studies show uncomfortable results arise after H. pylori infection was cured. These studies suggest that gastro-esophageal reflux disease (GERD) and gastro-doudenal erosion may increase after successful eradication of H. pylori. Recently, adenocarcinoma of the gastric cardia and esophagus increase in incidence. Reflux esophagitis and Barrett's esophagus are recognized as precancerous lesion of esophageal adenocarcinoma. It is uncertain the association of newly occurrence of GERD after H. pylori eradication and increase of esophageal adenocarcinoma. Although GERD may lead to adenocarcinoma, long term observations is necessary after H. pylori eradication.
幽门螺杆菌（H. pylori）感染被认为是多种胃十二指肠疾病的病原体。幽门螺杆菌的根除治疗可降低胃十二指肠溃疡的复发率，改善胃炎的组织学状况，并被认为在预防胃癌发生中发挥一定作用。然而，多项研究表明，幽门螺杆菌感染治愈后会出现一些不良结果。这些研究提示，成功根除幽门螺杆菌后，胃食管反流病（GERD）和胃十二指肠糜烂可能会增加。近年来，贲门癌和食管癌的发病率有所上升。反流性食管炎和巴雷特食管被认为是食管腺癌的癌前病变。幽门螺杆菌根除后新发生的GERD与食管腺癌增加之间的关联尚不确定。虽然GERD可能导致腺癌，但幽门螺杆菌根除后仍需长期观察。
