Kamp-Jensen M, Werner M U
H: S Hvidovre Hospital, smerteklinikken og akut smerteenhed, anaestesiologisk afdeling 532.
Ugeskr Laeger. 2001 Jan 22;163(4):454-8.
Gabapentin is a recently introduced anti-epileptic drug used as an adjuvant in partial and secondarily generalised tonic-clonic seizures. Its mechanism of action has not been fully elucidated, but it seems that gabapentin may regulate voltage-dependent calcium channels, presumably on a spinal level, in the nociceptive system. Two large, controlled clinical trials of painful diabetic neuropathy and postherpetic neuralgia have demonstrated its analgesic efficacy. The adverse effects associated with gabapentin treatment are relatively harmless, mild to moderate in severity, and usually transient, with tolerance developing 2-3 weeks after start of treatment. Gabapentin and tricyclic antidepressants are efficacious in the treatment of painful diabetic neuropathy and postherpetic neuralgia.
加巴喷丁是一种最近引入的抗癫痫药物，用作部分性发作和继发性全身性强直阵挛性发作的辅助用药。其作用机制尚未完全阐明，但加巴喷丁似乎可能调节电压依赖性钙通道，推测是在脊髓水平上，在伤害感受系统中发挥作用。两项关于疼痛性糖尿病神经病变和带状疱疹后神经痛的大型对照临床试验已证明其镇痛效果。与加巴喷丁治疗相关的不良反应相对无害，严重程度为轻至中度，通常是短暂的，在治疗开始后2至3周会产生耐受性。加巴喷丁和三环类抗抑郁药在治疗疼痛性糖尿病神经病变和带状疱疹后神经痛方面有效。
