Vinchon M, Ruchoux M M, Soto-Ares G, Nicolas R, Dhellemmes P
Department of Pediatric Neurosurgery, CHRU de Lille, France.
Childs Nerv Syst. 2001 Jan;17(1-2):31-6. doi: 10.1007/s003810000356.
Cerebellar gliomas (CGs) in children are generally associated with a favorable outcome; however, data regarding these tumors in very young children are scarce. We report on our experience with CGs in children less than 3 years old at surgery, compared with a second group older than 3 years. From 1991 to 1996, we operated on 7 children with CGs in the first group and 43 in the second. Psychomotor delay and regression were the first symptoms in 3 cases, and 3 had macrocrania. The tumor was totally removed in all cases. One child died intraoperatively of air embolism and subdural bleeding. Three had malignant tumors (grade 3 or 4). There was no operative mortality or malignancy in the second group of patients. With a mean follow-up of 33 months, all survivors in the first group are disease-free, with no or minimal symptoms, and attend normal schools. The clinical, surgical, and pathological features suggest that children under 3 years of age represent a specific subgroup of CGs.
儿童小脑胶质瘤（CGs）通常预后良好；然而，关于极小儿童期这些肿瘤的数据却很匮乏。我们报告了对3岁以下儿童进行CGs手术的经验，并与另一组3岁以上儿童进行了比较。1991年至1996年，我们对第一组7例CGs儿童和第二组43例进行了手术。精神运动发育迟缓及倒退是3例的首发症状，3例有巨头症。所有病例肿瘤均全切除。1例儿童术中死于空气栓塞和硬膜下出血。3例为恶性肿瘤（3级或4级）。第二组患者无手术死亡及恶性肿瘤发生。平均随访33个月，第一组所有幸存者均无疾病，症状轻微或无症状，且就读于正常学校。临床、手术及病理特征提示3岁以下儿童是CGs的一个特殊亚组。
