Prathiba V, Rao K S, Gupta P D
Central Leather Research Institute, Chennai, India.
Cytobios. 2001;104(405):43-51.
Keloids and hypertrophic scars are a result of aberrations of the normal wound healing processes of the skin. The expression of keratins, the proteins of an intermediate filament supergene family, closely parallel the division/differentiation of epithelial cells and therefore offer excellent molecular markers to examine wound healing. In this study, the expression of K5/K14, proliferation specific keratin polypeptides in normal skin, keloids and hypertrophic scars was analysed. Results indicated that unlike normal wounds and hypertrophic scars, keloid epidermis displayed increased expression of K5 and K14 at both the translational and transcriptional levels. The molecular mechanisms in the pathogenesis of keloids appear to be different from those of hypertrophic scars.
瘢痕疙瘩和增生性瘢痕是皮肤正常伤口愈合过程异常的结果。角蛋白是中间丝超基因家族的蛋白质，其表达与上皮细胞的分裂/分化密切平行，因此为研究伤口愈合提供了优秀的分子标记。在本研究中，分析了正常皮肤、瘢痕疙瘩和增生性瘢痕中增殖特异性角蛋白多肽K5/K14的表达。结果表明，与正常伤口和增生性瘢痕不同，瘢痕疙瘩表皮在翻译和转录水平上均显示K5和K14的表达增加。瘢痕疙瘩发病机制中的分子机制似乎与增生性瘢痕不同。
