Růzicka E, el Massioui F, Pillon B, Dubois B, Renault B, Agid Y
1st Medical Faculty, Charles University.
Sb Lek. 1999;100(2):85-99.
To ascertain whether variations in central dopaminergic transmission can differentially affect motor and cognitive processing, we studied the effects of apomorphine (APO) in 9 patients with Parkinson's disease (PD). The UPDRS motor scores and auditory event-related potentials (ERPs) obtained in the 'odd-ball' (OB) and in the 'covert orientation of attention' (COA) tasks were studied in the 'off' and in the 'on' state after an injection of APO. Although APO injection improved patients' motor status, it induced a significant increase in the latencies of the P2 and P3 ERP components in the OB. In the COA task, right-hand reaction times (RTs) were markedly shortened in the 'on' state while left hand RTs remained unchanged. The contrasting effects of dopaminergic stimulation on the motor performance and on some aspects of cognitive processing suggest the existence of complex interactions within pre- and postsynaptic brain dopamine receptors, and an intervention of segregated basal ganglia-prefrontal cortex loops in motor and cognitive behaviour.
为确定中枢多巴胺能传递的变化是否会对运动和认知加工产生不同影响，我们研究了阿扑吗啡（APO）对9例帕金森病（PD）患者的作用。在注射APO后的“关”期和“开”期，对患者在“odd-ball”（OB）任务和“注意力隐蔽定向”（COA）任务中获得的统一帕金森病评定量表（UPDRS）运动评分及听觉事件相关电位（ERP）进行了研究。尽管注射APO改善了患者的运动状态，但它导致OB任务中P2和P3 ERP成分的潜伏期显著延长。在COA任务中，“开”期右手反应时间（RTs）明显缩短，而左手RTs保持不变。多巴胺能刺激对运动表现和认知加工某些方面的不同影响表明，突触前和突触后脑多巴胺受体之间存在复杂的相互作用，并且在运动和认知行为中存在分离的基底神经节-前额叶皮层环路的干预。
