帕金森病患者的事件相关电位、反应时间和认知状态

Event-related potentials, reaction time, and cognitive state in patients with Parkinson's disease.

作者信息

Hayashi R, Hanyu N, Shindo M, Tamaru F, Yanagisawa N

机构信息

Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

Adv Neurol. 1993;60:429-33.

PMID:8420167

Abstract

ERPs, RT, and cognitive state in 53 patients with PD were studied. The peak latency of P300 and the RT in PD patients were significantly prolonged in the advanced stage of illness. The cognitive state in PD patients was characterized by impairment of attention, recent memory, and constructional ability in categories of the Folstein Mini-Mental State Examination. The significant association between neurophysiological and neuropsychological measurements suggests that these measurements reflect a disrupted aspect of cognitive function in PD patients.

摘要

对53例帕金森病患者的事件相关电位（ERPs）、反应时间（RT）和认知状态进行了研究。帕金森病患者P300的峰潜伏期和反应时间在疾病晚期显著延长。在Folstein简易精神状态检查表的类别中，帕金森病患者的认知状态表现为注意力、近期记忆和结构能力受损。神经生理学和神经心理学测量之间的显著关联表明，这些测量反映了帕金森病患者认知功能的一个受损方面。