Wiech K, Preissl H, Birbaumer N
Institut für Medizinische Psychologie und Verhaltensneurobiologie, Universität Tübingen.
Anaesthesist. 2001 Jan;50(1):2-12. doi: 10.1007/s001010050956.
Imaging techniques with high spatial and temporal resolution (PET,fMRI, MEG) provide detailed information about the brains' processing of pain. Structures detected by these techniques are not understood as pain centers but as nodal points of a dynamic network which is influenced by physiological and psychological input. Imaging techniques can be used for the investigation of different pain components. The neuronal network that encodes sensory-discriminative information consists of the primary and secondary somatosensory cortex which receive input from lateral thalamic nuclei. Information for the affective pain component reach the anterior cingulate cortex, insula and prefrontal cortex via medial thalamic nuclei. Until now only little is known about cortical structures mediating the cognitive pain component. In chronic pain the cortical and subcortical processing of nociceptive input is presumably modified. Reorganization in the primary somatosensory cortex is presented as an example of neuronal plasticity induced by chronic pain.
具有高空间和时间分辨率的成像技术（正电子发射断层扫描、功能磁共振成像、脑磁图）能提供有关大脑疼痛处理过程的详细信息。通过这些技术检测到的结构并非被理解为疼痛中枢，而是一个受生理和心理输入影响的动态网络的节点。成像技术可用于研究不同的疼痛成分。编码感觉辨别信息的神经网络由接收来自丘脑外侧核输入的初级和次级体感皮层组成。情感性疼痛成分的信息通过丘脑内侧核到达前扣带回皮层、脑岛和前额叶皮层。到目前为止，关于介导认知性疼痛成分的皮层结构知之甚少。在慢性疼痛中，伤害性输入的皮层和皮层下处理可能会发生改变。初级体感皮层的重组被作为慢性疼痛诱导神经元可塑性的一个例子呈现出来。
