Köveker G B
Department of General Surgery, City Hospital of Sindelfingen, Germany.
Int J Clin Pract. 2000 Nov;54(9):590-3.
Wound repair consists of a complex interaction of cellular and biochemical events. Several growth factors have been identified as regulatory polypeptides co-ordinating the healing process. Although it is not known precisely why chronic wounds do not follow the normal pattern of healing, diminished growth factor content and accelerated growth factor degradation may contribute to poor healing. Topical application of different factors exert stimulatory effects on wounds in animal models. Human data are limited but the most investigated compound is recombinant human platelet-derived growth factor-BB (rhPDGF-BB). PDGF-BB enhances granulation tissue formation and facilitates epithelialisation. Clinical trials in patients with 'hard to heal' diabetic foot ulcers demonstrated significant improvement in the 'healing rate' and the 'time to healing' compared with controls. Refinement of therapeutic strategies with growth factors will take place in the future.
伤口修复由细胞和生化事件的复杂相互作用组成。几种生长因子已被确定为协调愈合过程的调节多肽。虽然尚不清楚慢性伤口为何不遵循正常的愈合模式，但生长因子含量减少和生长因子降解加速可能导致愈合不良。在动物模型中，局部应用不同因子对伤口有刺激作用。人类数据有限，但研究最多的化合物是重组人血小板衍生生长因子-BB（rhPDGF-BB）。PDGF-BB可促进肉芽组织形成并促进上皮形成。对“难愈合”糖尿病足溃疡患者的临床试验表明，与对照组相比，“愈合率”和“愈合时间”有显著改善。未来将对生长因子治疗策略进行改进。
