Peyman G A, Bennett T O, Vlchek J
Ann Ophthalmol. 1975 Feb;7(2):279-88.
One dose of each prostaglandin preparation was injected into the vitreous body of the right eye of 64 rabbits. Doses less than 200mug caused no toxicity. Doses greater than 200mug exhibited the following changes observed by ophthalmoscopic observation, fluorescein angiography, histologic preparation, and electron microscopy: vascular leakage, vascular occlusion, hemorrhage, and retinal detachment. Electron micrographs revealed damaged retinal vascular endothelial cells. These changes were considered secondary toxic phenomena and did not occur at physiologic prostaglandin concentrations.
将每种前列腺素制剂的一剂注入64只兔子右眼的玻璃体中。剂量小于200微克未引起毒性。剂量大于200微克时，通过检眼镜观察、荧光素血管造影、组织学制备和电子显微镜观察到以下变化：血管渗漏、血管闭塞、出血和视网膜脱离。电子显微镜照片显示视网膜血管内皮细胞受损。这些变化被认为是继发性毒性现象，在生理前列腺素浓度下不会发生。
