Karlinskiĭ V M, Pozdniakova V P
Antibiotiki. 1975 Jan;20(1):86-8.
136 patients suffering from chronic cholecystitis were treated in the phase of exacerbation with antibiotics in combination with prodigiosan. It was found that inclusion of prodigiosan into the therapeutic complex had a positive effect on the immediate and late results of the treatment. Since intramuscular administration of prodigiosan was accompanied by a number of side effects, a method of the drug administration by means of electrophoresis on the area of the bile bladder was tested. It was shown that prodigiosan administered by the method of electrophoresis totally preserved its stimulating capacity with respect to the host. As with intramuscular administration of prodigiosan, the general reaction of the host and positive dynamics of the clinical and laboratory indices of the active process were observed and the content of lysozyme in the blood phagocytes reliably increased. The method of prodigiosan administration by means of electrophoresis was better tolerated by the patients and no side effects characteristic of the drug intramuscular administration were noted. When indicated, the use of prodigiosan by means of electrophoresis is recommended.
136例慢性胆囊炎患者在病情加重期接受抗生素联合灵菌红素治疗。结果发现,在治疗方案中加入灵菌红素对治疗的近期和远期效果均有积极影响。由于肌肉注射灵菌红素会伴随一些副作用,因此测试了一种通过在胆囊区域进行电泳给药的方法。结果表明,通过电泳给药的灵菌红素对机体的刺激能力完全得以保留。与肌肉注射灵菌红素一样,观察到机体的一般反应以及活动期临床和实验室指标的积极变化,并且血液吞噬细胞中的溶菌酶含量可靠增加。患者对电泳给药法的耐受性更好,未观察到肌肉注射该药所特有的副作用。如有指征,建议采用电泳法使用灵菌红素。