Olsen J D
Bayer Corporation, Agriculture Division, Animal Health, Shawnee Mission, Kansas, USA.
Vet Clin North Am Small Anim Pract. 2000 Nov;30(6):1337-55. doi: 10.1016/s0195-5616(00)06010-1.
Therapy of respiratory tract infections presents some unique challenges to the veterinary practitioner. These infections often involve underlying disease processes that have predisposed the patient to secondary bacterial infection and may complicate the response to therapy. Because of the diversity of microbial organisms that may colonize and invade the respiratory tract, treatment targeted at the infecting pathogens is best accomplished with bacterial culture and susceptibility testing. When these data are unavailable, rational antibiotic treatment should be based on familiarity with historical data and clinical experience. Optimal drug selection is based on predicted microbial susceptibility, drug distribution in the respiratory tract, and safety of the patient. Instituting the appropriate dosage regimen and duration of therapy maximizes the opportunity for a successful resolution of bacterial infections.
呼吸道感染的治疗给兽医从业者带来了一些独特的挑战。这些感染常常涉及潜在的疾病过程，这些过程使病畜易患继发性细菌感染，并可能使治疗反应复杂化。由于可能定植和侵入呼吸道的微生物种类繁多，针对感染病原体的治疗最好通过细菌培养和药敏试验来完成。当无法获得这些数据时，合理的抗生素治疗应基于对历史数据的熟悉程度和临床经验。最佳的药物选择基于预测的微生物敏感性、药物在呼吸道中的分布以及病畜的安全性。制定合适的给药方案和治疗持续时间可最大程度地提高成功解决细菌感染的机会。
