Ferlazzo G, Semino C, Melioli G
Laboratorio di Immunoterapia Cellulare, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, Centro di Biotecnologie Avanzate, Largo Rosanna Benzi, 10, 16132, Genova, Italy.
Immunol Lett. 2001 Feb 1;76(1):37-41. doi: 10.1016/s0165-2478(00)00323-0.
It has been widely demonstrated that natural killer (NK) cells are able to discriminate between normal and abnormal cells on the basis of the interaction of their NKRs with the MHC molecules expressed on the target cells. Recent studies showed that also normal dendritic cells are susceptible to NK cell-mediated lysis. In this work, the potential relationships between the expression of different surface molecules on both immature and mature DC and susceptibility to lysis have been investigated. The reduced density of HLA class I on the surface of immature DC resulted in the only permissive signal to NK cell mediated killing. On the contrary, the remarkable increase in HLA class I molecules detected during DC maturation was strictly related to the resistance to NK cell. Contemporary, no clear evidences of a role for other surface molecules modulated during DC maturation (CD80, CD83, CD86 and CD40), were obtained.
已有广泛证据表明，自然杀伤（NK）细胞能够根据其自然杀伤细胞受体（NKRs）与靶细胞上表达的主要组织相容性复合体（MHC）分子之间的相互作用，区分正常细胞和异常细胞。最近的研究表明，正常树突状细胞（DC）也易受NK细胞介导的裂解作用影响。在这项研究中，研究了未成熟和成熟DC上不同表面分子的表达与裂解敏感性之间的潜在关系。未成熟DC表面HLA I类分子密度降低，这是导致其对NK细胞介导的杀伤作用唯一敏感的信号。相反，在DC成熟过程中检测到的HLA I类分子显著增加，这与对NK细胞的抗性密切相关。同时，未获得明确证据表明在DC成熟过程中被调节的其他表面分子（CD80、CD83、CD86和CD40）发挥了作用。
