胞二磷胆碱在短暂性前脑缺血后是否会调节磷脂酶活性？
Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?
作者信息
Rao A M, Hatcher J F, Dempsey R J
机构信息
Department of Neurological Surgery, H4-330, Clinical Science Center, 600 Highland Avenue, University of Wisconsin-Madison, Madison, WI 53792-3232, USA.
出版信息
Brain Res. 2001 Mar 2;893(1-2):268-72. doi: 10.1016/s0006-8993(00)03280-7.
Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A(2) (rather than inhibiting phospholipase A(2) activity) but did not affect activities of PtdCho-phospholipases C and/or D, or phosphoinositide-phospholipase C. CDP-choline also provided significant protection for hippocampal CA(1) neurons.
沙土鼠前脑缺血10分钟/再灌注1天导致其海马体中总磷脂酰胆碱（PtdCho）、磷脂酰肌醇（PtdIns）和心磷脂显著减少。胞苷二磷酸胆碱可恢复心磷脂水平、PtdCho的花生四烯酸含量，部分但显著地恢复总PtdCho，且对PtdIns无影响。这些数据表明，胞苷二磷酸胆碱可防止磷脂酶A(2)的激活（而非抑制磷脂酶A(2)的活性），但不影响PtdCho - 磷脂酶C和/或D或磷酸肌醇 - 磷脂酶C的活性。胞苷二磷酸胆碱还为海马CA(1)神经元提供了显著的保护作用。
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