Yufu Y, Kimura M, Kawano R, Noguchi Y, Takatsuki H, Uike N, Ohshima K
Department of Hematology, National Kyushu Cancer Center Hospital, Fukuoka, Japan.
Bone Marrow Transplant. 2000 Dec;26(12):1339-41. doi: 10.1038/sj.bmt.1702721.
Post-transplant lymphoproliferative disorders (PTLD) of T cell type are a rare complication of solid organ and allogeneic hematopoietic cell transplantation (HCT), and usually are not associated with Epstein-Barr virus (EBV) infection. EBV-associated T cell PTLD has not been reported to occur after autologous HCT. We report an unusual case of T cell lymphoproliferation after autologous blood stem cell transplantation (ABSCT). A patient with relapsed Hodgkin's disease developed abdominal lymphadenopathy followed by atypical CD8+ lymphocytosis in the peripheral blood 30 months following ABSCT. DNA studies of the atypical lymphocytes demonstrated rearrangements of the T cell receptor beta gene and a clonal proliferation of EBV.
T细胞型移植后淋巴细胞增生性疾病（PTLD）是实体器官和异基因造血细胞移植（HCT）的一种罕见并发症，通常与爱泼斯坦-巴尔病毒（EBV）感染无关。自体HCT后尚未有EBV相关T细胞PTLD发生的报道。我们报告了1例自体造血干细胞移植（ABSCT）后发生T细胞淋巴细胞增生的罕见病例。1例复发性霍奇金病患者在ABSCT后30个月出现腹部淋巴结病，随后外周血出现非典型CD8+淋巴细胞增多。对非典型淋巴细胞的DNA研究显示T细胞受体β基因重排以及EBV的克隆性增殖。
