霍奇金淋巴瘤作为恶性胶质瘤自体造血细胞移植后移植后淋巴细胞增生性疾病的罕见表现。
Hodgkin's disease as unusual presentation of post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for malignant glioma.
作者信息
Zambelli Alberto, Lilleri Daniele, Baldanti Fausto, Scelsi Mario, Villani Laura, Da Prada Gian Antonio
机构信息
U.O. di Oncologia Medica I, IRCCS, Fondazione Salvatore Maugeri, Pavia, Italy.
出版信息
BMC Cancer. 2005 Aug 23;5:109. doi: 10.1186/1471-2407-5-109.
BACKGROUND
Post-transplant lymphoproliferative disorder (PTLD) is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT); following autologous HSCT only rare cases of PTLD have been reported. Here, a case of Hodgkin's disease (HD), as unusual presentation of PTLD after autologous HSCT for malignant glioma is described.
CASE PRESENTATION
60-years old man affected by cerebral anaplastic astrocytoma underwent subtotal neurosurgical excision and subsequent high-dose chemotherapy followed by autologous HSCT. During the post HSCT course, cranial irradiation and corticosteroids were administered as completion of therapeutic program. At day +105 after HSCT, the patient developed HD, nodular sclerosis type, with polymorphic HD-like skin infiltration.
CONCLUSION
The clinical and pathological findings were consistent with the diagnosis of PTLD.
背景
移植后淋巴细胞增生性疾病（PTLD）是实体器官和异基因造血干细胞移植（HSCT）的一种并发症；自体HSCT后仅报道过罕见的PTLD病例。本文描述了1例霍奇金淋巴瘤（HD），这是恶性胶质瘤自体HSCT后PTLD的一种不寻常表现。
病例介绍
一名60岁患有脑间变性星形细胞瘤的男性接受了神经外科次全切除，随后进行了大剂量化疗，接着进行了自体HSCT。在HSCT后的病程中，给予头颅照射和皮质类固醇作为治疗方案的补充。HSCT后第105天，患者发生了结节硬化型HD，并伴有多形性HD样皮肤浸润。
结论
临床和病理结果与PTLD的诊断一致。
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