Zambelli Alberto, Lilleri Daniele, Baldanti Fausto, Scelsi Mario, Villani Laura, Da Prada Gian Antonio
U.O. di Oncologia Medica I, IRCCS, Fondazione Salvatore Maugeri, Pavia, Italy.
BMC Cancer. 2005 Aug 23;5:109. doi: 10.1186/1471-2407-5-109.
Post-transplant lymphoproliferative disorder (PTLD) is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT); following autologous HSCT only rare cases of PTLD have been reported. Here, a case of Hodgkin's disease (HD), as unusual presentation of PTLD after autologous HSCT for malignant glioma is described.
60-years old man affected by cerebral anaplastic astrocytoma underwent subtotal neurosurgical excision and subsequent high-dose chemotherapy followed by autologous HSCT. During the post HSCT course, cranial irradiation and corticosteroids were administered as completion of therapeutic program. At day +105 after HSCT, the patient developed HD, nodular sclerosis type, with polymorphic HD-like skin infiltration.
The clinical and pathological findings were consistent with the diagnosis of PTLD.
移植后淋巴细胞增生性疾病（PTLD）是实体器官和异基因造血干细胞移植（HSCT）的一种并发症；自体HSCT后仅报道过罕见的PTLD病例。本文描述了1例霍奇金淋巴瘤（HD），这是恶性胶质瘤自体HSCT后PTLD的一种不寻常表现。
一名60岁患有脑间变性星形细胞瘤的男性接受了神经外科次全切除，随后进行了大剂量化疗，接着进行了自体HSCT。在HSCT后的病程中，给予头颅照射和皮质类固醇作为治疗方案的补充。HSCT后第105天，患者发生了结节硬化型HD，并伴有多形性HD样皮肤浸润。
临床和病理结果与PTLD的诊断一致。
