Shimoni A, Körbling M, Champlin R, Molldrem J
The Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.
Bone Marrow Transplant. 2000 Dec;26(12):1343-5. doi: 10.1038/sj.bmt.1702678.
A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma presented 60 days after high-dose chemotherapy and autologous stem cell transplantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis in the ears and extremities. Extensive work-up revealed the presence of cryofibrinogenemia and associated thrombotic vasculopathy. The patient was successfully treated with corticosteroids and therapeutic plasma exchange. However, she had recurrence of large cell lymphoma a few weeks later and died of progressive disease. Cryfibrinogenemia and skin necrosis may have occurred secondary to the imminent relapse, or as a rare complication of high-dose chemotherapy or treatment with interleukin-2.
一名34岁的弥漫性纵隔B细胞大细胞淋巴瘤女性患者，在接受大剂量化疗和自体干细胞移植60天后，以及接受白细胞介素-2进行移植后免疫治疗时，出现耳部和四肢皮肤坏死。全面检查发现存在冷纤维蛋白原血症及相关血栓性血管病变。患者接受皮质类固醇和治疗性血浆置换后成功治愈。然而，几周后她的大细胞淋巴瘤复发，最终死于疾病进展。冷纤维蛋白原血症和皮肤坏死可能是即将复发的继发表现，或者是大剂量化疗或白细胞介素-2治疗的罕见并发症。
