Susanna R, Medeiros F A
Glaucoma Service, Department of Ophthalmology, University of São Paulo, São Paulo, Brazil.
Curr Opin Ophthalmol. 2001 Apr;12(2):149-56. doi: 10.1097/00055735-200104000-00012.
The prostaglandin analogs are new exciting drugs added to the therapeutic armamentarium for patients with glaucoma. Several studies have evaluated the ocular hypotensive properties and side effects of latanoprost in different forms of glaucoma. This drug, seems to be the most effective intraocular pressure (IOP)-reducing agent currently available, and has a low incidence of ocular and systemic side effects. Fewer data are available regarding unoprostone, but the IOP-reducing effect of this drug seems to be comparable or slightly inferior to that of timolol and it produces fewer side effects. When compared with unoprostone, latanoprost has been shown to effect a greater reduction in IOP. A major drawback to the use of prostaglandin analogues is the lack of long-term experience such as that currently available for other classes of agents.
前列腺素类似物是添加到青光眼患者治疗药物库中的令人兴奋的新型药物。多项研究评估了拉坦前列素在不同类型青光眼中的降眼压特性和副作用。这种药物似乎是目前可用的最有效的降低眼压（IOP）药物，且眼和全身副作用的发生率较低。关于乌诺前列酮的数据较少，但这种药物的降眼压效果似乎与噻吗洛尔相当或略逊一筹，且副作用较少。与乌诺前列酮相比，拉坦前列素已被证明能更大程度地降低眼压。使用前列腺素类似物的一个主要缺点是缺乏像目前其他类药物那样的长期经验。
