Zhou A, Feng F, Shi Y
Cancer Hospital, CAMS & PUMC, Beijing 10002, China.
Zhonghua Xue Ye Xue Za Zhi. 2000 Nov;21(11):584-6.
To explore the clinical and pathological characteristics of true histiocytic lymphoma.
The clinical and pathological data of 10 true histiocytic lymphoma patients admitted between 1986 and 1996 to our hospital was retrospectively reviewed.
True histiocytic lymphoma accounted for 0.6% of non-Hodgkin's lymphoma(NHL) admitted in this period to our hospital. Enzymes associated with true histiocytic lymphoma were detected in all the 10 cases. The tumor cells were excluded from T/B lymphoid origin in 6 cases by immunohistochemistry. Eight cases received chemotherapy + irradiation +/- excision of primary lesion, 1 simply received irradiation and 1 received bone marrow transplantation. The response rate was 100%, with a 1, 3 and 5 year survival rate of 100%, 90% and 70%, respectively. The expected 10 year disease free survival rate is 40%.
True histiocytic lymphoma is a rare subset of NHL. Those originated from lymph node are sensitive to chemotherapy and irradiation with a favorable prognosis.
探讨真性组织细胞淋巴瘤的临床及病理特征。
回顾性分析1986年至1996年我院收治的10例真性组织细胞淋巴瘤患者的临床及病理资料。
真性组织细胞淋巴瘤占同期我院收治的非霍奇金淋巴瘤（NHL）的0.6%。10例患者均检测到与真性组织细胞淋巴瘤相关的酶。免疫组化结果显示，6例患者的肿瘤细胞排除了T/B淋巴细胞来源。8例患者接受了化疗+放疗+/-原发灶切除，1例单纯接受放疗，1例接受了骨髓移植。缓解率为100%，1年、3年和5年生存率分别为100%、90%和70%。预计10年无病生存率为40%。
真性组织细胞淋巴瘤是NHL中一种罕见的亚型。起源于淋巴结的真性组织细胞淋巴瘤对化疗和放疗敏感，预后良好。
