Kasper C E
Doctoral Programs, Johns Hopkins University, School of Nursing, USA.
Biol Res Nurs. 1999 Jul;1(1):4-11. doi: 10.1177/109980049900100102.
The purpose of this investigation was to describe and compare various methods of recovering atrophied fast-twitch skeletal muscle following long-term impaired physical mobility. An animal model was used to study morphological adaptations of atrophied plantaris muscles to the effects of 28 days of hindlimb suspension (HS) followed by either sedentary recovery or run training during a 28-day recovery period. Significant atrophy, demonstrated by decreased mean fiber area (MFA, micron 2), occurred during the 28-day period of HS. However, run training following long-term atrophy induced by HS did not result in the high levels of frank muscle damage and type IIC fibers previously reported in slow-twitch soleus muscle following long-term (28 days) atrophy.
本研究的目的是描述和比较长期身体活动受限后恢复萎缩快肌骨骼肌的各种方法。使用动物模型研究萎缩的跖肌对28天的后肢悬吊（HS）影响的形态学适应，随后在28天的恢复期进行久坐恢复或跑步训练。在HS的28天期间出现了明显的萎缩，表现为平均纤维面积（MFA，平方微米）减小。然而，HS诱导的长期萎缩后的跑步训练并未导致先前报道的慢肌比目鱼肌在长期（28天）萎缩后出现的高水平明显肌肉损伤和IIC型纤维。
