Sabra R, Shuman S
Department of Pharmacology and Therapeutics, Faculty of Medicine, American University of Beirut, P.O. Box 11-0236/37, Beirut, Lebanon.
Eur J Pharmacol. 2001 Feb 16;413(2-3):287-94. doi: 10.1016/s0014-2999(01)00770-1.
This study examined the influence of phenobarbital, an inducer of hepatic enzymes, on Na(+) handling, hemodynamics and liver function (measured by the rate constant of elimination of aminopyrine in the aminopyrine breath test) after partial portal vein ligation. Rats were randomized to drink either phenobarbital + water or water only for 10 days and then underwent either sham operation or partial portal vein ligation. The aminopyrine rate constant of elimination and Na(+) balance were measured daily before and after surgery; after surgery, hemodynamic measurements were obtained daily in a subset of rats. Phenobarbital raised the baseline aminopyrine rate constant of elimination. Partial portal vein ligation, but not sham operation, caused equivalent reductions in the aminopyrine rate constant of elimination in phenobarbital- and water-treated groups, such that the aminopyrine rate constant of elimination remained higher in the former. Na(+) balance increased significantly in partial portal vein ligation + water, but not sham + water rats on day 1 and then decreased on days 2 and 3. In contrast, neither sham + phenobarbital nor partial portal vein ligation + phenobarbital rats had a significant increase in Na(+) balance. Partial portal vein ligation resulted in vasodilation on day 3 after surgery in the water-treated rats, an effect that was prevented by treatment with phenobarbital. These results support previous suggestions that a reduction in liver function triggers renal Na(+) retention in this model. Vasodilation is not necessary for the latter effect, but also appears to be dependent on a reduction in liver function.
本研究考察了肝酶诱导剂苯巴比妥对部分门静脉结扎后钠（Na⁺）处理、血流动力学和肝功能（通过氨基比林呼吸试验中氨基比林消除速率常数测定）的影响。将大鼠随机分为两组，一组饮用苯巴比妥+水，另一组仅饮用10天的水，然后分别接受假手术或部分门静脉结扎。在手术前后每天测量氨基比林消除速率常数和Na⁺平衡；术后，对一部分大鼠每天进行血流动力学测量。苯巴比妥提高了氨基比林消除的基线速率常数。部分门静脉结扎而非假手术，使苯巴比妥处理组和水处理组的氨基比林消除速率常数出现同等程度的降低，以至于前者的氨基比林消除速率常数仍较高。在部分门静脉结扎+水组大鼠中，第1天Na⁺平衡显著增加，而假手术+水组大鼠未出现此情况，随后在第2天和第3天Na⁺平衡下降。相比之下，假手术+苯巴比妥组和部分门静脉结扎+苯巴比妥组大鼠的Na⁺平衡均未显著增加。部分门静脉结扎导致水处理组大鼠术后第3天血管舒张，而苯巴比妥处理可防止这种效应。这些结果支持了先前的观点，即在该模型中肝功能降低会引发肾脏Na⁺潴留。血管舒张并非产生后一种效应所必需，但似乎也依赖于肝功能降低。
