Paydaş S, Sahin B, Gönlüşen G, Hazar B, Zorludemir S
Department of Oncology, Faculty of Medicine, Cukurova University, 01330 Balcali, Adana, Turkey.
Leuk Res. 2001 Mar;25(3):221-5. doi: 10.1016/s0145-2126(00)00111-9.
Plasmacytoma (Pm) is a plasma cell (PC) neoplasia consisting of PCs and some of them show progression to multiple myeloma. But there is no clear indicators predicting this progression. In this study, MUC1 expression was evaluated in Pm cases to determine the predictive value and was compared with histopathologic grade which is known to be a prognostic indicator in Pm. Nine of 31 cases with Pm showed MUC1 expression. Only two of the 18 cases with mature morphology showed MUC1 expression while seven of 13 cases with immature morphology showed MUC1 expression and this was statistically significant (P<0.006). Additionally, four of 11 cases with BM involvement showed MUC1 expression while five of 20 cases without BM involvement showed MUC1 expression. There was a trend MUC1 expression with BM involvement but there was not statistically significant association between MUC1 expression and BM involvement. We found that MUC1 expression is associated with immature morphology which is an important prognostic indicator in Pm and by analogy MUC1 expression may be an additional prognostic indicator in patients with Pm.
浆细胞瘤（Pm）是一种由浆细胞（PC）构成的肿瘤，其中一些会进展为多发性骨髓瘤。但目前尚无明确的指标可预测这种进展。在本研究中，对Pm病例的MUC1表达进行评估以确定其预测价值，并与已知为Pm预后指标的组织病理学分级进行比较。31例Pm病例中有9例显示MUC1表达。18例形态成熟的病例中仅有2例显示MUC1表达，而13例形态不成熟的病例中有7例显示MUC1表达，这具有统计学意义（P<0.006）。此外，11例有骨髓受累的病例中有4例显示MUC1表达，而20例无骨髓受累的病例中有5例显示MUC1表达。MUC1表达与骨髓受累存在一定趋势，但MUC1表达与骨髓受累之间无统计学意义上的关联。我们发现MUC1表达与不成熟形态相关，而不成熟形态是Pm的一个重要预后指标，由此类推，MUC1表达可能是Pm患者的另一个预后指标。
