Fukushima M, Kitahara T, Takeda N, Saika T, Uno A, Kubo T
Department of Otolaryngology, Osaka University Medical School, 2-2 Yamadaoka, Suita, 565-0871, Japan.
Neuroscience. 2001;102(1):159-66. doi: 10.1016/s0306-4522(00)00457-7.
Several lines of evidence have suggested that acetylcholine is a possible neurotransmitter/neuromodulator involved in vestibular compensation. Further, the central vestibular system, oculo- and spino-motor neurons and peripheral vestibular efferents contain abundant cholinergic neurons. However, details of cholinergic effective sites during vestibular compensation remain to be clarified. In the present study, we selectively damaged rat vestibulo-floccular and vestibulo-uvulonodular cholinergic mossy fibers using ethylcholine mustard aziridinium ions. In these treated animals, unilateral labyrinthectomy caused more severe vestibulo-ocular deficits especially during the initial stage. From these findings we suggest that vestibulo-floccular and vestibulo-uvulonodular cholinergic mossy fibers contribute to the restoration of a balance between intervestibular nuclear activities for the induction of vestibular compensation during the initial stage.
多条证据表明，乙酰胆碱可能是参与前庭代偿的一种神经递质/神经调质。此外，中枢前庭系统、眼动和脊髓运动神经元以及外周前庭传出纤维中含有丰富的胆碱能神经元。然而，前庭代偿过程中胆碱能有效位点的细节仍有待阐明。在本研究中，我们使用氮芥乙胆碱离子选择性损伤大鼠前庭-绒球和前庭-小舌结节胆碱能苔藓纤维。在这些接受治疗的动物中，单侧迷路切除术导致更严重的前庭眼动缺陷，尤其是在初始阶段。根据这些发现，我们认为前庭-绒球和前庭-小舌结节胆碱能苔藓纤维有助于在初始阶段诱导前庭代偿时恢复前庭核间活动之间的平衡。
