Seong S Y, Choi M S, Kim I S
Department of Microbiology and Immunology, Seoul National University College of Medicine and Institute of Endemic Disease, Seoul National University Medical Research Center, 28 Yongon-dong, Chongno-gu, 110-799, Seoul, South Korea.
Microbes Infect. 2001 Jan;3(1):11-21. doi: 10.1016/s1286-4579(00)01352-6.
Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930. Infections by virulent strains are characterized by fever, rash, eschar, pneumonia, myocarditis, and disseminated intravascular coagulation. Here we review the general aspects of O. tsutsugamushi and immune responses in terms of inflammation, protective immune mechanisms, and immunogenic antigens.
恙虫病东方体是一种专性细胞内细菌，于1930年首次被分离出来。强毒株感染的特征为发热、皮疹、焦痂、肺炎、心肌炎和弥散性血管内凝血。在此，我们从炎症、保护性免疫机制和免疫原性抗原方面综述恙虫病东方体及免疫反应的一般情况。
