Dhawan A, Trivedi P, Cheeseman P, Baker A J, Howard E R, Mieli-Vergani G
Department of Child Health, King's College Hospital, London, England.
J Pediatr Surg. 2001 Mar;36(3):443-6. doi: 10.1053/jpsu.2001.21622.
The aim of this study was to assess whether serum concentrations of hyaluronic acid (HA), measured at diagnosis is an early biochemical marker of prognosis in biliary atresia.
Serum HA was measured at diagnosis using a radiometric assay in 84 infants with biliary atresia (BA), and related to outcome by 5 years of age.
Serum HA was higher in the 29 patients who died or required liver transplant by 5 years of age compared with the 56 who survived to 5 years without transplant (490 +/- 216 microg/L v 262 +/- 163 microg/L; P <.001, 95% confidence intervals of the difference 145 to 311 microg/L).
High serum concentrations of HA at diagnosis may help to identify at an early stage those patients with BA who have a poor prognosis and will require liver transplant by 5 years of age.
本研究旨在评估诊断时测量的血清透明质酸（HA）浓度是否为胆道闭锁预后的早期生化标志物。
采用放射免疫分析法对84例胆道闭锁（BA）婴儿在诊断时测定血清HA，并与5岁时的预后相关联。
与56例存活至5岁且未进行移植的患儿相比，29例在5岁前死亡或需要肝移植的患儿血清HA水平更高（490±216μg/L对262±163μg/L；P<.001，差异的95%置信区间为145至311μg/L）。
诊断时血清HA浓度高可能有助于早期识别那些预后不良且5岁前需要肝移植的BA患儿。
