辅助性T细胞发育中的稳定性与定向分化

Stability and commitment in T helper cell development.

作者信息

Asnagli H, Murphy K M

机构信息

Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St. Louis, MO 63110, USA.

出版信息

Curr Opin Immunol. 2001 Apr;13(2):242-7. doi: 10.1016/s0952-7915(00)00210-7.

DOI:10.1016/s0952-7915(00)00210-7

PMID:11228419

Abstract

Specialized effector activities that are required to eliminate various pathogens involve cytokines produced by specialized CD4(+) T cells subsets, dogmatically termed Th1 and Th2 cells. Despite some oversimplifications, this paradigm is useful for organizing the complex pathways that control forward and backward movements along the road of T cell differentiation. Effective immune memory relies, in part, on the maintenance of the T helper phenotype. This review will address basic issues that relate to the maintenance or reversibility of Th1/Th2 states within the CD4(+) T cell lineage.

摘要

清除各种病原体所需的特异性效应活动涉及由特定CD4(+) T细胞亚群产生的细胞因子，传统上称为Th1和Th2细胞。尽管有些过于简化，但这种模式有助于梳理控制T细胞分化进程中向前和向后运动的复杂途径。有效的免疫记忆部分依赖于T辅助细胞表型的维持。本综述将探讨与CD4(+) T细胞谱系中Th1/Th2状态的维持或可逆性相关的基本问题。