Luo Y, Roth G S
Gerontology Research Center, NIA/NIH, Baltimore, MD 21224, USA.
Antioxid Redox Signal. 2000 Fall;2(3):449-60. doi: 10.1089/15230860050192224.
Aging is accompanied by a decline of functions controlled by the central dopaminergic system, such as reduced locomotor activity, motivation, impairment of memory formation, and learning deficits. The molecular mechanisms underlying age-related impairment of dopaminergic functions are unknown. Current literature and our own recent work, which are reviewed and summarized in the present paper, suggest that dopamine oxidative stress and its subsequent signaling may contribute to the aging of dopaminergic system.
衰老伴随着中枢多巴胺能系统所控制的功能衰退，如运动活性降低、动机缺乏、记忆形成受损以及学习缺陷。多巴胺能功能与年龄相关损伤的分子机制尚不清楚。本文所综述和总结的当前文献及我们自己最近的研究表明，多巴胺氧化应激及其后续信号传导可能导致多巴胺能系统的衰老。
