精神分裂症中的物质滥用与冲动性、寻求刺激或快感缺失有关吗？
Is substance abuse in schizophrenia related to impulsivity, sensation seeking, or anhedonia?
作者信息
Dervaux A, Baylé F J, Laqueille X, Bourdel M C, Le Borgne M H, Olié J P, Krebs M O
机构信息
Service Hospitalo-Universitaire de Santé Mentale et Thérapeutique, Université René Descartes, Paris, France.
出版信息
Am J Psychiatry. 2001 Mar;158(3):492-4. doi: 10.1176/appi.ajp.158.3.492.
OBJECTIVE
The authors compared impulsivity, sensation seeking, and anhedonia in a group of schizophrenic patients with and without lifetime substance abuse or dependence.
METHOD
Patients (N=100) with schizophrenia or schizoaffective disorder (per DSM-III-R criteria) were assessed with the Composite International Diagnostic Interview's section on psychoactive substance use disorder, the Positive and Negative Syndrome Scale, the Barratt Impulsivity Scale, the Zuckerman Seeking Sensation Scale, and the Chapman Physical Anhedonia Scale.
RESULTS
The mean scores for impulsivity and sensation seeking were higher in the group with substance abuse (N=41) than in the group without substance abuse (N=59). No significant difference between groups was found regarding physical anhedonia.
CONCLUSIONS
As in the general population, high levels of impulsivity and sensation seeking are associated with substance abuse in patients with schizophrenia.
目的
作者比较了一组有或无终生物质滥用或依赖的精神分裂症患者的冲动性、感觉寻求和快感缺乏情况。
方法
采用复合国际诊断访谈中关于精神活性物质使用障碍的部分、阳性与阴性症状量表、巴拉特冲动性量表、祖克曼感觉寻求量表和查普曼身体快感缺乏量表，对100名符合精神分裂症或分裂情感性障碍（根据DSM-III-R标准）的患者进行评估。
结果
物质滥用组（N = 41）的冲动性和感觉寻求平均得分高于无物质滥用组（N = 59）。两组在身体快感缺乏方面未发现显著差异。
结论
与普通人群一样，精神分裂症患者中高水平的冲动性和感觉寻求与物质滥用有关。
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