Dai Weine, Zhou Hui, Møller Arne, Wei Ping, Hu Kesong, Feng Kezhuang, Han Jie, Li Qi, Liu Xun
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China.
Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China.
Brain Sci. 2022 Jul 24;12(8):974. doi: 10.3390/brainsci12080974.
Methamphetamine use disorder (MUD) is a chronic brain disorder that involves frequent failures of inhibitory control and relapses into methamphetamine intake. However, it remains unclear whether the impairment of inhibitory control in MUD is proactive, reactive or both. To address this issue, the current study used the conditional stop-signal task to assess proactive and reactive inhibitory control in 35 MUD patients with long-term abstinence and 35 matched healthy controls. The results showed that MUD patients with long-term abstinence had greater preparation costs than healthy controls, but did not differ in performance, implying a less efficient utilization of proactive inhibitory control. In contrast, MUD patients exhibited intact reactive inhibitory control; reactive but not proactive inhibitory control was associated with high sensation seeking in MUD patients with long-term abstinence. These findings suggest that proactive and reactive inhibitory control may be two different important endophenotypes of addiction in MUD patients with long-term abstinence. The current study provides new insight into the uses of proactive and reactive inhibitory control to effectively evaluate and precisely treat MUD patients with long-term abstinence.
甲基苯丙胺使用障碍（MUD）是一种慢性脑部疾病，涉及抑制控制频繁失败以及复吸甲基苯丙胺。然而，MUD中抑制控制的损害是主动的、反应性的还是两者皆有，仍不清楚。为解决这一问题，本研究使用条件性停止信号任务，评估35名长期戒断的MUD患者和35名匹配的健康对照的主动和反应性抑制控制。结果显示，长期戒断的MUD患者比健康对照有更高的准备成本，但在表现上无差异，这意味着主动抑制控制的利用效率较低。相比之下，MUD患者表现出完整的反应性抑制控制；在长期戒断的MUD患者中，反应性而非主动抑制控制与高感觉寻求有关。这些发现表明，主动和反应性抑制控制可能是长期戒断的MUD患者成瘾的两种不同重要内表型。本研究为利用主动和反应性抑制控制有效评估和精准治疗长期戒断的MUD患者提供了新见解。
