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[抗肿瘤化疗研究。十、β-硝基苯乙烯及复合硝基乙烯衍生物的细胞毒性和抗肿瘤活性]

[Research in antitumoral chemotherapy. X. Cytotoxic and antitumoral activity of beta-nitrostyrenes and of composed nitrovinyl derivatives].

作者信息

Doré J C, Viel C

出版信息

Farmaco Sci. 1975 Feb;30(2):81-109.

PMID:1123038
Abstract

In previous work the antitumoral cytotoxicity of beta-nitrostyrenes obtained by simplification of the aristolochic acid molecule was demonstrated. The effect of modifying the three characteristic parts of the beta-nitrostyrene molecule has now been investigated. The results obtained in vitro and in vivo allow hypothesis of a mechanism of action for the various beta-nitrostyrene and nitrovinyl compounds studied and definition of the maximum simplification compatible with retention of biological activity.

摘要

在之前的工作中，已证明通过简化马兜铃酸分子得到的β-硝基苯乙烯具有抗肿瘤细胞毒性。现在研究了修饰β-硝基苯乙烯分子三个特征部分的效果。体外和体内实验结果有助于推测所研究的各种β-硝基苯乙烯和硝基乙烯化合物的作用机制，并确定与生物活性保留相容的最大简化程度。

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[New synthetic cytotoxic and antitumoral agents derived from aristolochic acid, an antitumoral nitrophenanthrenic acid extracted from Aristolochiaceae].[源自马兜铃酸的新型合成细胞毒性和抗肿瘤剂，一种从马兜铃科植物中提取的抗肿瘤硝基菲酸]
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