Lei J Y, Middleton L P, Guo X D, Duray P H, McWilliams G, Linehan W M, Merino M J
Laboratory of Pathology and Surgical Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hum Pathol. 2001 Feb;32(2):233-6. doi: 10.1053/hupa.2001.22009.
Renal cell carcinoma (RCC) is the most common malignant tumor of the adult kidney, and its incidence has been steadily rising. RCC consists of several subtypes, each of which has its own clinical features, and cytogenetic and molecular characteristics. Recognizing histologic patterns of RCC is important not only for correct diagnosis, but also for providing insight into the biological behavior of the tumor and subsequent appropriate medical care for the patient. Pigments other than hemosiderin has been observed in RCC, but none of them have been proved to be melanin. Melanotic tumors, either primary or metastatic, are rare in the kidney. We present an unusual case of melanin-pigmented clear cell RCC with melanocytic differentiation, an unusual variant that may lead to errors in diagnosis and treatment.
肾细胞癌（RCC）是成人肾脏最常见的恶性肿瘤，其发病率一直在稳步上升。RCC由几种亚型组成，每种亚型都有其自身的临床特征、细胞遗传学和分子特征。认识RCC的组织学模式不仅对正确诊断很重要，而且对于深入了解肿瘤的生物学行为以及随后为患者提供适当的医疗护理也很重要。在RCC中已观察到除含铁血黄素以外的色素，但均未被证实为黑色素。原发性或转移性黑色素瘤在肾脏中都很罕见。我们报告了一例罕见的具有黑素细胞分化的黑色素沉着性透明细胞RCC病例，这种不寻常的变体可能导致诊断和治疗错误。
