Igaz P
Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Semmelweis Egyetem, Budapest.
Orv Hetil. 2001 Jan 28;142(4):169-71.
The therapy of bacterial infections is currently a difficult problem of the contemporary medicine, mainly due to the increasing spread of resistance to conventional antibiotics and to the appearance of multi-resistant bacterial strains. Although the gene-encoded antimicrobial peptides were described for a while their intensive research and study of their possible clinical applications has started only in the recent years. These antimicrobial peptides appear to form part of the most ancient defense mechanisms of the phylogenesis by exerting cytotoxic (mainly membrane damaging) effects against many bacteria. In this review the author attempts to make a brief synopsis--from a medical point of view--of the most important antimicrobial peptides and their possible clinical applications.
细菌感染的治疗是当代医学目前面临的一个难题，主要是由于对传统抗生素耐药性的日益蔓延以及多重耐药菌株的出现。尽管基因编码的抗菌肽已被描述了一段时间，但对其深入研究以及对其可能的临床应用的研究仅在近年来才开始。这些抗菌肽似乎通过对许多细菌发挥细胞毒性（主要是膜损伤）作用，构成了系统发育中最古老的防御机制的一部分。在这篇综述中，作者试图从医学角度对最重要的抗菌肽及其可能的临床应用做一个简要概述。
