Kew M C
Medical Research Council/CANSA/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Clin Liver Dis. 2000 Feb;4(1):257-68. doi: 10.1016/s1089-3261(05)70107-0.
Although gratifying progress has been made during the 20th century, much remains to be achieved. The principal objective must be prevention of HCC. Prevention of HBV-related tumors is already feasible, and prevention of HCV-related and aflatoxin-induced tumors should soon become possible. Not all HCCs are yet accounted for causatively, and the remaining risk factors need to be identified. Until primary prevention can be accomplished, attention must also be directed to obtaining a complete understanding of the pathogenesis of HCC so that strategies for secondary and tertiary prevention can be formulated and instituted. Finally, the search for effective anticancer treatment must continue.
尽管在20世纪已取得了令人欣慰的进展，但仍有许多工作有待完成。主要目标必须是预防肝癌。预防与乙肝相关的肿瘤已经可行，预防与丙肝相关的肿瘤以及黄曲霉毒素诱发的肿瘤也应很快成为可能。并非所有肝癌的病因都已明确，其余的风险因素仍有待确定。在实现一级预防之前，还必须致力于全面了解肝癌的发病机制，以便制定和实施二级及三级预防策略。最后，寻找有效的抗癌治疗方法的工作必须继续。
