Van der Meeren A, Lebaron-Jacobs L
Institut de Protection et de Sûreté Nucléaire, Département de Protection de la santé de l'Homme et de Dosimétrie, Fontenay-aux-Roses, France.
Can J Physiol Pharmacol. 2001 Feb;79(2):140-3.
The effects of an 8 Gy gamma total body irradiation (TBI) on exploration and locomotion activities as well as temperature were studied in C57BL6/J mice. Survival, body weight, and blood cell counts were also assessed in irradiated mice treated with placebo or interleukin (IL)-4. The efficacy of IL-4 treatment on improvement in exploration activity was evaluated. The study was carried out from 3 h to 30 days following exposure. Our results showed a biphasic response to irradiation concerning the exploration activity of mice. Irradiated mice had reduced activity as early as 3 h after exposure, with recovery of activity within 24 h. The exploration activity again decreased 4 days after irradiation and the recovery occurred slowly after day 17. IL-4 ameliorated the exploration status in mice in both phases. The locomotion activity was studied using a telemetry apparatus. A similar pattern to that of the exploration data was observed, with a minimal activity observed between days 13 and 17. A radiation-induced hypothermia was also noticed over the same time period.
在C57BL6/J小鼠中研究了8 Gy全身γ照射（TBI）对探索和运动活动以及体温的影响。还对接受安慰剂或白细胞介素（IL）-4治疗的受照射小鼠的存活率、体重和血细胞计数进行了评估。评估了IL-4治疗对改善探索活动的疗效。该研究在暴露后3小时至30天进行。我们的结果显示，小鼠的探索活动对辐射有双相反应。受照射小鼠在暴露后3小时就出现活动减少，24小时内活动恢复。照射后4天探索活动再次下降，17天后恢复缓慢。IL-4在两个阶段均改善了小鼠的探索状态。使用遥测装置研究运动活动。观察到与探索数据相似的模式，在第13天至17天之间活动最少。在同一时期还注意到辐射诱导的体温过低。
