Bahceci M, Tuzcu A, Akkus M, Yaldiz M, Ozbay A
University of Dicle, School of Medicine, Departments of Endocrinology and Metabolism, Diyarbakir, Turkey.
Eat Weight Disord. 1999 Sep;4(3):128-32. doi: 10.1007/BF03339728.
Ten male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5 +/- 5, at sixth month 268 +/- 19 g), whereas those of the rats fed with standard chow did not increase significantly (basal 177 +/- 6.4, at sixth month 220 +/- 10 g). At the sixth month, mean body fat percentages were 36.3 +/- 6.7% and 24.2 +/- 5.4% respectively. Both total cholesterol-triglyceride levels and mean serum leptin levels were also higher than in the overfed rats (p < 0.01 and p < 0.05 respectively). The livers of all rats were histopathologically normal.
High-fat diet resulting in an increased body fat percentage in rats is associated with hyperleptinemia, hypercholesterolemia and hypertriglyceridemia.
10只雄性Wistar白化大鼠在8至12周龄期间，连续6个月高脂饮食（除标准大鼠饲料外，每天给予40克/千克体重的人造黄油）。10只雄性大鼠在同一时期给予标准饲料。高脂喂养大鼠的体重随时间增加（基础体重171.5±5克，第6个月时为268±19克），而喂食标准饲料的大鼠体重没有显著增加（基础体重177±6.4克，第6个月时为220±10克）。在第6个月时，平均体脂百分比分别为36.3±6.7%和24.2±5.4%。高脂喂养大鼠的总胆固醇-甘油三酯水平和平均血清瘦素水平也高于对照组（分别为p<0.01和p<0.05）。所有大鼠的肝脏组织病理学检查均正常。
导致大鼠体脂百分比增加的高脂饮食与高瘦素血症、高胆固醇血症和高甘油三酯血症有关。
