Saadoun D, Cacoub P, Mahoux D, Sbai A, Piette J C
Service de médecine interne, hôpital de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75651 Paris, France.
Rev Med Interne. 2001 Feb;22(2):172-6. doi: 10.1016/s0248-8663(00)00307-6.
Vaccines may be responsible for adverse effects, mainly local fugitive and benign reactions. However, few cases of systemic vasculitis have been described. We report three new cases, suggesting the responsibility of vaccination in starting or reactivating systemic vasculitis.
We report two cases in a 64- and a 68-year-old woman with polymyalgia rheumatica and temporal arteritis after influenza and tetanus vaccination respectively, and one case in a 30-year-old man with periarteritis nodosa after hepatitis B vaccination.
Knowledge of such complications deserve to be expanded in order to: 1) avoid re-immunisations which are likely to result in more serious consequences; 2) avoid aggravation or reactivation of a vasculitis; and 3) control serology before hepatitis B vaccination in all persons at risk of HBV infection.
疫苗可能会导致不良反应，主要是局部短暂性和良性反应。然而，仅有少数系统性血管炎病例被描述过。我们报告了三例新病例，提示疫苗接种可能引发或重新激活系统性血管炎。
我们报告了两例分别在64岁和68岁女性中的病例，她们在接种流感疫苗和破伤风疫苗后分别出现了风湿性多肌痛和颞动脉炎，以及一例在30岁男性中的病例，他在接种乙肝疫苗后出现了结节性多动脉炎。
对此类并发症的认识应予以扩展，以便：1）避免可能导致更严重后果的再次免疫接种；2）避免血管炎的加重或重新激活；3）对所有有感染乙肝病毒风险的人在接种乙肝疫苗前进行血清学检查。
