乙醇和花生四烯酸途径抑制剂对胃黏膜细胞保护作用效果的影响

Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection.

作者信息

Lutnicki K, Szpringer E, Czerny K, Ledwozyw A

机构信息

Department of Pathophysiology, Medical Academy, ul. Jaczewskiego 8, 20-090 Lublin, Poland.

出版信息

Folia Morphol (Warsz). 2001;60(1):47-56.

PMID:11234698

Abstract

Cytoprotection in the stomach, consisting in the mucus secretion, mucous circulation intensification and bicarbonate secretion to the gastric lumen, is highly dependent on the products of arachidonic acid pathway and peroxidative-antioxidative balance. The aim of the paper was to examine the effects of selected inhibitors of arachidonic acid pathway on the natural protective system of the gastric mucosa exposed to 50% ethanol. The results show that leukotrienes, thromboxane and oxygen reactive forms significantly impair the protective function of the gastric mucosa while prostaglandins and antioxidant enzymes act protectively.

摘要

胃中的细胞保护作用，包括黏液分泌、黏液循环增强以及向胃腔分泌碳酸氢盐，高度依赖于花生四烯酸途径的产物以及过氧化-抗氧化平衡。本文的目的是研究花生四烯酸途径的某些抑制剂对暴露于50%乙醇的胃黏膜天然保护系统的影响。结果表明，白三烯、血栓素和氧反应形式会显著损害胃黏膜的保护功能，而前列腺素和抗氧化酶则起到保护作用。