Schreiber R C, Krivacic K, Kirby B, Vaccariello S A, Wei T, Ransohoff R M, Zigmond R E
Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4975, USA.
Neuroreport. 2001 Mar 5;12(3):601-6. doi: 10.1097/00001756-200103050-00034.
EDI-immunoreactive macrophages, absent from the superior cervical ganglia (SCG) of normal rats, appear in these ganglia within 48h after postganglionic axotomy. Further, resident macrophages show changes after axotomy. Since chemokines function as chemoattractants and activators of leukocytes, the effects of axotomy on chemokine expression in the SCG were examined. Within 6 h after nerve transection, increases were seen in mRNA levels for monocyte chemoattractant protein (MCP)-1. MCP-1 mRNA was concentrated in a population of neurons, while MCP-1 protein was localized to endothelial cells. This axotomy-induced neuronal MCP-1 expression may trigger the infiltration and/or activation of macrophages in SCG after injury.
正常大鼠颈上神经节（SCG）中不存在EDI免疫反应性巨噬细胞，但在节后轴突切断后48小时内，这些神经节中会出现此类细胞。此外，轴突切断后，常驻巨噬细胞会发生变化。由于趋化因子具有白细胞趋化剂和激活剂的功能，因此研究了轴突切断对SCG中趋化因子表达的影响。神经切断后6小时内，单核细胞趋化蛋白（MCP）-1的mRNA水平升高。MCP-1 mRNA集中在一群神经元中，而MCP-1蛋白则定位于内皮细胞。这种轴突切断诱导的神经元MCP-1表达可能会触发损伤后SCG中巨噬细胞的浸润和/或激活。
