[他莫昔芬与羟基自由基（OH-）和/或超氧羟基自由基（HO2-）的辐射氧化反应]
[Radiolytic oxidation of tamoxifen with the free radicals OH- and/or HO2-].
作者信息
Leguéné C, Clavère P, Jore D, Gardès-Albert M
机构信息
Laboratoire de Chimie-Physique, UMR 8601, Centre national de la recherche scientifique, Université René Descartes, Paris, France.
出版信息
Can J Physiol Pharmacol. 2001 Feb;79(2):184-8.
Tamoxifen is the most widely used antiestrogen in the treatment of breast cancer. In this work, we have studied its antioxidant properties. We have investigated the ability of tamoxifen to scavenge, in vitro, OH and (or) HO2 free radicals that are produced by water radiolysis. Aqueous solutions of tamoxifen of concentrations ranging between 10(-5) and 2.5 x 10(-5) M have been irradiated (gamma 137Cs) in aerated acidic medium (H3PO4 10(-3) M or HCOOH 10(-1) M). The results show that tamoxifen reacts quantitatively with OH free radicals but does not react with HO2 free radicals under our experimental conditions.
他莫昔芬是治疗乳腺癌时使用最广泛的抗雌激素药物。在这项研究中，我们对其抗氧化特性进行了研究。我们研究了他莫昔芬在体外清除水辐解产生的·OH和（或）HO₂自由基的能力。浓度在10⁻⁵至2.5×10⁻⁵ M之间的他莫昔芬水溶液在充气酸性介质（10⁻³ M磷酸或10⁻¹ M甲酸）中进行了辐照（¹³⁷Cs γ射线）。结果表明，在我们的实验条件下，他莫昔芬能与·OH自由基发生定量反应，但不与HO₂自由基反应。
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