Hirose S
Center of Psychiatry and Neurology, Fukui Prefectural Hospital, Japan.
Psychiatry Clin Neurosci. 2001 Feb;55(1):79-80. doi: 10.1046/j.1440-1819.2001.00789.x.
There are reports that abrupt withdrawal of various selective serotonin re-uptake inhibitors, such as fluvoxamine, can elicit in patients various withdrawal symptoms. Fluvoxamine has been widely used in Japan for approximately 1 year. However, there have been no case reports of withdrawal symptoms following abrupt fluvoxamine discontinuation in Japan. The author reports a case where the abrupt discontinuation of fluvoxamine produced restlessness in a depressed patient. The restlessness disappeared soon after the reinstatement of treatment with fluvoxamine. This case report suggests that clinicians should carefully scrutinize a patient's compliance to fluvoxamine as the withdrawal symptoms observed following abrupt discontinuation might be regarded as a relapse of depression or side-effects of the medicine.
有报告称，突然停用各种选择性5-羟色胺再摄取抑制剂，如氟伏沙明，可使患者出现各种戒断症状。氟伏沙明在日本已广泛使用约一年。然而，在日本尚无关于突然停用氟伏沙明后出现戒断症状的病例报告。作者报告了一例突然停用氟伏沙明后使一名抑郁症患者出现烦躁不安的病例。在用氟伏沙明恢复治疗后不久，烦躁不安症状消失。该病例报告提示，临床医生应仔细检查患者对氟伏沙明的依从性，因为突然停药后观察到的戒断症状可能被视为抑郁症复发或药物的副作用。
